Reacción #78044

ord-7689ffb0135244b39fb4391353a7ea55

Ecuación de reacción

Cl.FC1(F)CCNCC1
4,4-difluoro-piperidine hydrochloride
CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)O
Boc-(L)-isoleucine
→
CCC(C)[C@H](N)C(=O)N1CCC(F)(F)CC1.Cl
(S)-2-amino-1-(4,4-difluoro-piperidin-1-yl)-3-methyl-pentan-1-one hydrochloride

Reactantes

Cl.FC1(F)CCNCC1
4,4-difluoro-piperidine hydrochloride
CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)O
Boc-(L)-isoleucine
—
Example 1

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

(S)-2-amino-1-(4,4-difluoro-piperidin-1-yl)-3-methyl-pentan-1-one hydrochloride was prepared from 4,4-difluoro-piperidine hydrochloride and Boc-(L)-isoleucine as described in Example 1 (mp 190-192° C.).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06710040B1uspto-grants-2004_03