Reacción #77960

Ecuación de reacción

tert-butyl nitrite

dimethyl disulfide

4-bromo-3-methyl-2-methylthioaniline

dimethyl disulfide

→

2-methyl-3,4-dimethylthiobromobenzene

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónFor work-up, the solid is filtered off with suction
2. 2
   workup.ADDITIONthe filtrate is diluted with methylene chloride
3. 3
   Extracciónextracted with dilute hydrochloric acid
4. 4
   LavadoThe organic phase is washed with saturated aqueous NaHCO3 solution
5. 5
   Secadodried over sodium sulfate
6. 6
   Filtraciónfiltered off
7. 7
   Concentraciónconcentrated
8. 8
   OtroExcess dimethyl disulfide is removed under oil pump vacuum

Procedimiento

14.8 g (129 mmol) of tert-butyl nitrite and 20 g of copper powder are initially charged in 50 ml of dimethyl disulfide, and a solution of 20 g (86 mol) of 4-bromo-3-methyl-2-methylthioaniline in 100 ml of dimethyl disulfide is added dropwise at from 50 to 55° C. The mixture is subsequently stirred at 50° C. for 4 hours. For work-up, the solid is filtered off with suction and the filtrate is diluted with methylene chloride and extracted with dilute hydrochloric acid. The organic phase is washed with saturated aqueous NaHCO3 solution, dried over sodium sulfate, filtered off and concentrated. Excess dimethyl disulfide is removed under oil pump vacuum.

Fuente