Reacción #77857

Ecuación de reacción

N-bromosuccimide

3,4-dihydro-2H-pyran

acetic acid

→

2-acetoxy-3-bromo-tetrahydropyran

Rendimiento 73.0%

Disolventes

diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with 50 ml of water three times
2. 2
   LavadoThe organic layer was washed with 1N NaHCO3 solution
3. 3
   Otrodried
4. 4
   Concentraciónconcentrated under a reduced pressure

Procedimiento

To the solution of N-bromosuccimide (4.5 g ) in acetic acid (14.5 ml), was added dropwise 2.3 ml of 3,4-dihydro-2H-pyran at 10° C. The reaction mixture was diluted with 50 ml of diethyl ether and washed with 50 ml of water three times. The organic layer was washed with 1N NaHCO3 solution, dried, and then concentrated under a reduced pressure to give 4.1 g of 2-acetoxy-3-bromo-tetrahydropyran as a colorless oil (yield: 73%).

Fuente