Reacción #77782

Ecuación de reacción

5-bromo-indoline

tert.-butyldicarbonate

→

5-Bromo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Rendimiento 89.0%

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated in vacuo
2. 2
   Otrotriturated with hexane

Procedimiento

4 g (20 mmol) 5-bromo-indoline in 50 ml CH2Cl2 were treated with 4.4 g (20 MMOL) di.-tert.-butyldicarbonate at RT over night. The reaction mixture was concentrated in vacuo and triturated with hexane to yield 5.3 g (89%) 5-Bromo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester as colorless solid, MS: 297 (M, 1Br).

Fuente