Reacción #766

Ecuación de reacción

CS(=O)(=O)Cc1cc(N)cc

N#Cc1cnn2c(NC3CC3)cc

→

CS(=O)(=O)Cc1cc(Nc2c

Rendimiento 35.0%

Disolventes

CC(=O)N(C)C

Condiciones de reacción

Procedimiento

In a 40mL vial (t=g) was 5-chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (88 mg, 0.38 mmol), [Reactants], and cesium carbonate (135 mg, 0.41 mmol) in DMA (0.5 mL) ([VOLUME]),Pd2(dba)3 (17.24 mg, 0.02 mmol) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (21.79 mg, 0.04 mmol) were added. to give a brown suspension. The vial was filled with N2, 150C microwave for 30 min. LCMS showed completion. added DMF(3 mL), filtered through celite. concentrated. The residue was washed with EtOAc and water, MeoH to give about 55mg light brown solid

Fuente