Reacción #76562

Ecuación de reacción

ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate

→

7-fluoro-4-hydroxy-3-quinolinecarboxylic acid

Rendimiento 92.2%

Disolventes

sodium hydroxide

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Temperaturaat reflux for 3 hours during which time a solution
3. 3
   Otrowas obtained
4. 4
   Filtraciónit was filtered
5. 5
   Filtraciónthrough filter paper under vacuum
6. 6
   OtroThe resulting precipitate was collected
7. 7
   Lavadowashed with water
8. 8
   Otrodried

Procedimiento

A suspension of ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate (65 g, 0.28 mol) in 10% sodium hydroxide (250 mL) was heated at reflux for 3 hours during which time a solution was obtained. The reaction mixture was allowed to cool to ambient temperature and then it was filtered through filter paper under vacuum. The filtrate was acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with water and then dried to provide 53.5 g of 7-fluoro-4-hydroxy-3-quinolinecarboxylic acid as a white solid.

Fuente