Reacción #76517

Ecuación de reacción

product

[(1,2,3,4-Tetrahydro-6-nitro-5-quinolinyl)amino]oxo-acetic acid ethyl ester

methyl iodide

cesium carbonate

→

[Methyl(1,2,3,4-tetrahydro-6-nitro-5-quinolinyl)-amino]oxo-acetic acid ethyl ester

Rendimiento 93.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe inorganic salts were removed by filtration
2. 2
   Otrothe filtrate evaporated
3. 3
   workup.DISSOLUTIONThe residue was dissolved in methylene chloride
4. 4
   Filtraciónfiltered
5. 5
   Otroevaporated
6. 6
   OtroThe product was then used without further purification (0.86 g, 93% yield)

Procedimiento

A mixture of the product from Example 87 (0.87 g, 3 mmol), methyl iodide (0.51 g, 3.6 mmol) and cesium carbonate (1.17 g, 3.6 mmol) in 15 mL of acetonitrile was stirred at room temperature for 2 hours. The inorganic salts were removed by filtration and the filtrate evaporated. The residue was dissolved in methylene chloride, filtered and evaporated. The product was then used without further purification (0.86 g, 93% yield).

Fuente