Reacción #765

Ecuación de reacción

N#Cc1cnn2c(NC3CC3)cc

CC(=O)N(C)c1ccc2cc[n

→

CC(=O)N(C)c1ccc2ccn(

Rendimiento 15.9%

Disolventes

CC(=O)N(C)C

Condiciones de reacción

Procedimiento

In microwave tube, added 5-chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (84mg), N-(1H-indol-6-yl)-N-methylacetamide (67 mg), Pd2(dba)3 (16 mg), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (20mg) cesium carbonate(129 mg) in anhydrous DMA (0.5mL). under microwave 150C for 30 min. the mixture was filtered. washed with MeOH. combinde organic solvent, dried to dryness. The residue solid was washed with MeOH to give about 22mg offwhite solid (product.

Fuente