Reacción #7629

Ecuación de reacción

acetylchloride

2,6-diamino-4-chloro-pyrimidine

isocyanoacetic acid methyl ester

furfural

→

1-acetyl-5-amino-7-chloro-2-furan-2-yl-3-(methoxycarbonylmethylamino)imidazo[1,2-a]pyrimidin-1-ium chloride

Disolventes

perchloric acid

Condiciones de reacción

Procedimiento

Example 27 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2,6-diamino-4-chloro-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) isocyanoacetic acid methyl ester solution (0.2 M, DCM), 0.500 ml (0.15 mmol) furfural solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

Fuente