Reacción #7627
ord-d226efdb4de84acf86dab433a563b9d9
Ecuación de reacción
acetylchloride
2,6-diamino-4-chloro-pyrimidine
cyclohexylisonitrile
acetaldehyde
→
1-acetyl-5-amino-7-chloro-3-cyclohexylamino-2-methyl-imidazo[1,2-a]pyrimidin-1-ium chloride
Reactivos
Ninguno
Disolventes
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
Example 25 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2,6-diamino-4-chloro-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) acetaldehyde solution (0.3 M, DCM) and 10 μL perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.