Reacción #76197

Ecuación de reacción

Carvedilol

→

Carvedilol

III

2-(2-Methoxyphenoxy)ethylamine

Disolventes

water

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISSOLUTIONwas completely dissolved
2. 2
   TemperaturaThe solution is then cooled with agitation to 10° C. over a period of 3 hours
3. 3
   Filtraciónthe product is filtered

Procedimiento

Carvedilol (40 g) was dissolved in 150 ml of ethanol and 40 ml water. The solution was heated with agitation to 60-70° C. until the solid material was completely dissolved. The solution is then cooled with agitation to 10° C. over a period of 3 hours. After stirring the suspension for an additional 2.75 hours, the product is filtered. Pure Carvedilol Form III (35 g) was obtained.

Fuente