Reacción #76193

Ecuación de reacción

Carvedilol

water

→

Carvedilol

III

2-(2-Methoxyphenoxy)ethylamine

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITThe solution was left at room temperature
2. 2
   workup.STIRRINGwithout stirring for about 80 h
3. 3
   Filtraciónthe crystals were filtered through a buchner
4. 4
   Otrodried in a desiccator at room temperature (connected to air pump) until constant weight

Procedimiento

Carvedilol (4 g) was dissolved in 39 mL pyridine by stirring at room temperature. 70 mL of water was then added dropwise until crystallization began. The solution was left at room temperature without stirring for about 80 h, then the crystals were filtered through a buchner and dried in a desiccator at room temperature (connected to air pump) until constant weight to yield Carvedilol Form III.

Fuente