Reacción #76191

Ecuación de reacción

Carvedilol

→

carvedilol

III

2-(2-Methoxyphenoxy)ethylamine

Disolventes

—

mixture

Ethanol

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaby heating the mixture
2. 2
   TemperaturaThe solution was cooled
3. 3
   workup.WAITleft at room temperature
4. 4
   workup.STIRRINGwithout stirring for about 14 hours
5. 5
   Filtraciónthe crystals were filtered through a buchner funnel
6. 6
   Lavadorinsed twice with about 10 ml cold (4° C.) 96% ethanol
7. 7
   Otrodried in a desiccator at room temperature (connected to air pump) until constant weight

Procedimiento

Carvedilol (4 g) was dissolved in 45 mL of a mixture of 96% Ethanol and 4% water by heating the mixture under stirring in a 55° C. water bath. The solution was cooled and left at room temperature without stirring for about 14 hours, the crystals were filtered through a buchner funnel, rinsed twice with about 10 ml cold (4° C.) 96% ethanol, and dried in a desiccator at room temperature (connected to air pump) until constant weight to yield carvedilol Form III.

Fuente