Reacción #75953

Ecuación de reacción

NaHCO3

sulfuryl chloride

ethyl isobutyrylacetate

toluene

toluene

Water

→

product

Rendimiento 84.0%

Ethyl 2-chloro-3-oxo-3-phenylpropanoate

Rendimiento 84.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroresulting two-phase mixture
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   LavadoThe combined organic extracts were washed with brine
4. 4
   Secadodried over anhydrous sodium sulfate
5. 5
   Otroevaporated

Procedimiento

A solution of sulfuryl chloride (12.4 mmol) in toluene (5 mL) was added dropwise via an additional funnel to a solution of ethyl isobutyrylacetate (12.4 mmol) in toluene (20 mL) over 5 minutes at room temperature. The resulting mixture was stirred at room temperature overnight. Water was added slowly and resulting two-phase mixture was basified with saturated NaHCO3 and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over anhydrous sodium sulfate, and evaporated to afford 2.2 g (84%) of product as a pale yellow oil: MH+=227.0, retention time (LC-MS)=2.77 min.

Fuente