Reacción #75935

ord-2dd43d3ec2b44a48900afbe6dea479ec

Ecuación de reacción

Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1-c1ccc(Br)cc1
4-(4-bromo-phenyl)-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole
COc1ccc(B(O)O)cc1
4-methoxy-benzeneboronic acid
COc1ccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)cc4)oc3C)c2)cc1
title compound
COc1ccc(-c2cccc(-c3nc(-c4ccc(C(F)(F)F)cc4)oc3C)c2)cc1
4-(4′-Methoxy-biphenyl-3-yl)-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otrowas obtained as a white solid, mp 93-94° C.

Procedimiento

The title compound was prepared from 4-(4-bromo-phenyl)-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole, and 4-methoxy-benzeneboronic acid in substantially the same manner, as described in Example 1 step c, and was obtained as a white solid, mp 93-94° C.; MS m/e 409 (M+);

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06699896B1uspto-grants-2004_03