Reacción #75876

Ecuación de reacción

Amlodipine free base

Nicotinic acid

amlodipine

→

amlodipine nicotinate

Rendimiento 85.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was heated
2. 2
   Temperaturaat reflux
3. 3
   workup.DISSOLUTIONwas completely dissolved
4. 4
   OtroThe solids formed
5. 5
   Otrowere isolated by filtration
6. 6
   Lavadowashed with ethyl acetate
7. 7
   Otrodried under reduced pressure

Procedimiento

Amlodipine free base (4.09 g) was added to 40 mL of ethanol. The mixture was heated at reflux and stirred until the solid was completely dissolved. Nicotinic acid (1.23 g) was added to the amlodipine solution and then the mixture was slowly cooled down to 0° C. within one hour. The solids formed were isolated by filtration, washed with ethyl acetate and dried under reduced pressure to yield 4.51 g of amlodipine nicotinate.

Fuente