Reacción #75814

Ecuación de reacción

sodium bicarbonate

1-[1-(piperidin-4-yl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one

diisopropylethylamine

ethyl chloroformate

→

title compound

1-[1-(1-ethoxycarbonylpiperidin-4-yl)-piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one

Disolventes

chloroform

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   SecadoThe organic layer was dried over sodium sulfate
2. 2
   Concentraciónconcentrated
3. 3
   Otrothe resulting residue was purified by silica gel column chromatography (chloroform/methanol=10/1)

Procedimiento

Forty-one (41) mg of 1-[1-(piperidin-4-yl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one.di-trifluoroacetate was dissolved in 5 ml of dichloromethane, and to which 25 mg of diisopropylethylamine and 11 mg of ethyl chloroformate were added, followed by stirring overnight. The reaction mixture was distributed between chloroform and saturated aqueous sodium bicarbonate solution. The organic layer was dried over sodium sulfate, concentrated, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol=10/1). Thus 22 mg of the title compound was obtained as a colorless, amorphous substance.

Fuente