Reacción #75796

Ecuación de reacción

4-benzoylbenzoic acid

4-(4-amino-2-butyl -1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butaneamine

→

N1-[4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyl]-4-benzoylbenzamide

Rendimiento 18.0%

Condiciones de reacción

Procedimiento

Using the general method of Example 112 Part B, 4-benzoylbenzoic acid (72 mg, 0.32 mmole) was reacted with 4-(4-amino-2-butyl -1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butaneamine (100 mg, 0.32 mmol) to provide 30 mg of N1-[4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyl]-4-benzoylbenzamide as a white solid. Mass-spec (M+1=521.31).

Fuente