Reacción #75704

Ecuación de reacción

HCl

2-Methylthioquinoline-4-carboxylic acid methyl ester

sodium hydroxide

→

title compound

Rendimiento 104.2%

2-Methylthioquinoline-4-carboxylic acid

Rendimiento 104.2%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISSOLUTIONhad dissolved
2. 2
   OtroThe precipitated solid was separated by filtration
3. 3
   Otrodried

Procedimiento

2-Methylthioquinoline-4-carboxylic acid methyl ester (0.40 g) in methanol:2N sodium hydroxide (2:1, 45 ml) was heated at 60° C. until all solid had dissolved. Volume of solvent was reduced to (15 ml) at reduced pressure and acidified with 2N HCl (16 ml). The precipitated solid was separated by filtration and dried to give the title compound (0.39 g). 1H NMR δ: 2.68 (3H, s), 7.56 (1H, m), 7.75-7.80 (2H, m), 7.96 (1H, d, J=8.2 Hz), 8.55 (1H, d), 13.91 (1H, brs).

Fuente