Reacción #75648

Ecuación de reacción

sodium hydroxide

3,5-dichloroaniline

ethylglyoxalate

styrene

trifluoroacetic acid

→

Compound 15

5,7-dichloro-4-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

Disolventes

ethanol

acetonitrile

Condiciones de reacción

Procedimiento

Compound 15 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol styrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.

Fuente