Reacción #75590

Ecuación de reacción

potassium hydrogen fluoride

benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate

→

title compound

Rendimiento 87.0%

Benzyl 4-fluoromethyl-4-hydroxy-1-piperidinecarboxylate

Rendimiento 87.0%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   Filtraciónit was filtered through Celite
3. 3
   OtroThe filtrate was evaporated

Procedimiento

3.2 g of potassium hydrogen fluoride and 610 mg tetra-n-butyl ammonium dihydrogen trifluoride were added to 5 g of benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate, and it was stirred at 120° C. for 7 hr. After cooling, methylene chloride was added thereto and it was filtered through Celite. The filtrate was evaporated, and the resulting residue was subjected to silica gel column chromatography to give 4.7 g of the title compound.

Fuente