Reacción #75586

Ecuación de reacción

benzyl 4-methylene-1-piperidinecarboxylate

phthalic acid

sodium bicarbonate

→

benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate

Rendimiento 71.9%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction solution was evaporated
2. 2
   workup.ADDITIONEthyl acetate was added to the resulting residue which
3. 3
   Lavadowas then washed with water and brine
4. 4
   Secadodried over anhydrous magnesium sulfate
5. 5
   Filtraciónfiltered
6. 6
   OtroThe filtrate was evaporated

Procedimiento

14.7 g of benzyl 4-methylene-1-piperidinecarboxylate was dissolved in 300 ml methanol, 20.4 g of phthalic acid monoperacid magnesium salt and 13.3 g of sodium bicarbonate were added thereto, and the mixture was stirred at room temperature for 7.5 hr. The reaction solution was evaporated. Ethyl acetate was added to the resulting residue which was then washed with water and brine, dried over anhydrous magnesium sulfate, and then filtered. The filtrate was evaporated, and then subjected to silica gel column chromatography to give 11.3 g of benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate.

Fuente