Reacción #75395

Ecuación de reacción

7,7-dimethyl-2-phenethyl-5-(2-chloro-ethyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione

2-(3,4-dimethoxy-phenyl)-ethylamine

→

7,7-Dimethyl-2-phenethyl-5-[2-(2-(3,4-dimethoxy-phenyl)ethylamino)-ethyl]-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione dihydrochloride

Disolventes

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   Extracciónextracted with water
3. 3
   OtroThe organic phase was evaporated
4. 4
   workup.DISSOLUTIONthe residue was dissolved in acetone
5. 5
   OtroThe dihycrochloride was precipitated from the acetone solution with ethereal hydrochloric acid

Procedimiento

2.8 gm of 7,7-dimethyl-2-phenethyl-5-(2-chloro-ethyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione were heated at 150° C. for 40 minutes with 5 ml of 2-(3,4-dimethoxy-phenyl)-ethylamine. After cooling, the mixture was dissolved in ether, and the solution was several times extracted with water weakly acidified with acetic acid. The organic phase was evaporated, and the residue was dissolved in acetone. The dihycrochloride was precipitated from the acetone solution with ethereal hydrochloric acid.

Fuente