Reacción #75351

Ecuación de reacción

sodium

3,4-dihydro-2H-pyran-2-carboxylic acid

hydrogen

→

Tetrahydropyran-2-carboxylic acid

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónwas filtered
2. 2
   Otrothe solvents removed in vacuo
3. 3
   Extracciónextracted with chloroform
4. 4
   workup.DISTILLATIONDistillation
5. 5
   Otrogave 143.8 g

Procedimiento

210 g. of the sodium salt of 3,4-dihydro-2H-pyran-2-carboxylic acid dissolved in 2 liters methanol and hydrogenated at 3 atmosphere pressure over 60 g. haney nickel catalyst. After hydrogen uptake was complete the catalyst was filtered and the solvents removed in vacuo. The residue was acidified with concentrated hydrochloric acid and extracted with chloroform. Distillation gave 143.8 g. product, b.p. 75°-80° C./0.4 mm ND25 =1.4633.

Fuente