Reacción #75321

Ecuación de reacción

N-benzyloxycarbonyl-L-alanyl-L-proline ethylamide

hydrobromic acid

ether

→

L-alanyl-L-proline ethylamide hydrobromide

Rendimiento 82.0%

Disolventes

—

4-N

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe ether decanted from the oil
2. 2
   workup.DISSOLUTIONThe oil was then dissolved in methanol
3. 3
   Otrothe product crystallising out on the addition of ethyl acetate

Procedimiento

1.81 g (0.0052 mol) of N-benzyloxycarbonyl-L-alanyl-L-proline ethylamide were stirred for 1 hour in 10 ml of 4-N hydrobromic acid in acetic acid. To the solution were added 150 ml of dry ether and, after stirring for a few minutes, the oil was allowed to settle. The mixture was cooled to -60° C. and the ether decanted from the oil and discarded. The oil was then dissolved in methanol, the product crystallising out on the addition of ethyl acetate. There were obtained 1.25 g (82%) of L-alanyl-L-proline ethylamide hydrobromide of melting point 202°-204° C.

Fuente