Reacción #75294

Ecuación de reacción

sodium bicarbonate

p-(hexafluoro-2-hydroxy-2-propyl)-N-methylaniline

chloroacetyl isothiocyanate

→

2-[4-(Hexafluoro-2-Hydroxy-2-Propyl)-N-Methylanilino]-2-Thiazolin-4-One

Disolventes

dimethoxyethane

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONPour the reaction mixture onto water
2. 2
   ExtracciónExtract with ether
3. 3
   Otrodry
4. 4
   Concentraciónconcentrate
5. 5
   OtroRecrystallize from ether
6. 6
   Otroto obtain the product, m.p. 240°-242° C.

Procedimiento

To p-(hexafluoro-2-hydroxy-2-propyl)-N-methylaniline (2.73 gm., 0.01 mole) in dimethoxyethane (40 ml), add chloroacetyl isothiocyanate (1.50 gm., 0.011 mole) and stir 1 hr. Pour the reaction mixture onto water and neutralize with sodium bicarbonate. Extract with ether, dry and concentrate. Recrystallize from ether to obtain the product, m.p. 240°-242° C.

Fuente