Reacción #74993

ord-1bae79cdb4cd473f92543be6b20fce4c

Ecuación de reacción

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Rifamycin S

dimethylformamide

1,3,5-tri-(tert.-butyl)-hexahydro-1,3,5-triazine

→

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rifampicin

Reactantes

1-amino-4-methylpiperazine

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Rifamycin S

dimethylformamide

1,3,5-tri-(tert.-butyl)-hexahydro-1,3,5-triazine

Reactivos

Ninguno

Disolventes

acetic acid

Condiciones de reacción

Condiciones detalladas

See reaction.notes.procedure_details.

Tratamiento posterior

1
workup.ADDITIONadded directly

Procedimiento

15 g. Rifamycin S are dissolved in 50 ml. dimethylformamide and 5.5 g. 1,3,5-tri-(tert.-butyl)-hexahydro-1,3,5-triazine are added to the solution. The reaction mixture is then kept at 75° C. for about 3 hours and 1-amino-4-methylpiperazine, acidified with acetic acid, added directly according to the procedure described in Example 1, followed by analogous working up to give substantially pure rifampicin.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04174320uspto-grants-1979_11