Reacción #748648

Ecuación de reacción

lithium tri-tert-butoxy-aluminohydride tetrahydrofuran

tert-butyl methyl 2,2-dimethyl-malonate

ammonium chloride

ethyl acetate

→

titled compound

Rendimiento 82.9%

3-Hydroxy-2,2-dimethyl-propionic acid tert-butyl ester

Rendimiento 82.9%

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was heated
2. 2
   Temperaturato reflux for 2 hours
3. 3
   Otrothe organic layer was separated
4. 4
   Lavadowashed with water
5. 5
   Secadoa saturated brine, dried over magnesium sulfate
6. 6
   Concentraciónconcentrated in vacuo

Procedimiento

1M lithium tri-tert-butoxy-aluminohydride/tetrahydrofuran solution (14 ml) was added dropwise to a solution of tert-butyl methyl 2,2-dimethyl-malonate (1.12 g) in tetrahydrofuran (30 ml) under nitrogen atmosphere over 15 minutes and the mixture was heated to reflux for 2 hours. The reaction mixture was cooled to room temperature, a saturated ammonium chloride aq. solution and ethyl acetate were added and the organic layer was separated, washed with water and a saturated brine, dried over magnesium sulfate and concentrated in vacuo to give the titled compound (800 mg). MS (m/z): 175 [M+H]+.

Fuente