Reacción #74764

Ecuación de reacción

1-Chloro-2(5-methyl-4-imidazolylmethylthio)ethane hydrochloride

potassium thiocyanate

→

2-(5-methyl-4-imidazolylmethylthio)ethylthiocyanate

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture was evaporated to dryness
2. 2
   Extracciónextracted with chloroform
3. 3
   SecadoThe chloroform extracts were dried (MgSO4)
4. 4
   Otroevaporated to a residue which
5. 5
   Otrowas recrystallised from acetonitrile

Procedimiento

1-Chloro-2(5-methyl-4-imidazolylmethylthio)ethane hydrochloride (2.1 g) and potassium thiocyanate (0.97 g) were heated together under reflux in ethanol (50 ml) for 3 days. The mixture was evaporated to dryness and the residue was taken up in water, basified with sodium carbonate and extracted with chloroform. The chloroform extracts were dried (MgSO4) and evaporated to a residue which was recrystallised from acetonitrile to give 2-(5-methyl-4-imidazolylmethylthio)ethylthiocyanate m.p. 101°-103°. (Found: C, 45.3; H, 5.3; N, 19.5; S, 29.3. C8H11N3S2 requires: C, 45.0; H, 5.2; N, 19.7; S, 30.1%).

Fuente