Reacción #74753

Ecuación de reacción

NaOH

2-(p-chlorobenzylidene)-1-indanone

H2O2

→

2-(p-Chlorobenzylidene)-1-indanone oxide

Disolventes

MeOH

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe product separates during the course of the reaction (5 hours at 35°-38°)
2. 2
   OtroCrystallization (of 9.7 g) from 70 ml of MeCN
3. 3
   Otrogives 8.8 g (86%) of nearly colorless solid

Procedimiento

Ten grams (0.039 mole) of 2-(p-chlorobenzylidene)-1-indanone is converted to the epoxide in 1 liter of MeOH, using 9.6 g (0.085 mole) of 30% H2O2 and 9.6 ml (0.039 mole) of 16% NaOH, as described in Example 1. Since the starting material is poorly soluble in MeOH it is oxidized as a suspension and the product separates during the course of the reaction (5 hours at 35°-38°). The crude yield is 10 g (94%); m.p. 162°-164°. Crystallization (of 9.7 g) from 70 ml of MeCN gives 8.8 g (86%) of nearly colorless solid; m.p. 165°-167°.

Fuente