Reacción #747091

Ecuación de reacción

hydrogen peroxide

3-amino-2-chloro-6-methylphenol hydrochloride

4-(pyrrolidin-1-yl)aniline dihydrochloride

ammonium hydroxide

→

3-amino-2-chloro-6-methyl-4-[(4-pyrrolidin-1-ylphenyl)imino]cyclohexa-2,5-dien-1-one

Rendimiento 53.9%

Disolventes

water

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITThe mixture is left
2. 2
   Otrothe precipitate formed
3. 3
   Filtraciónis filtered off

Procedimiento

1.94 g of 3-amino-2-chloro-6-methylphenol hydrochloride are added to 2.35 g of 4-(pyrrolidin-1-yl)aniline dihydrochloride in solution in 15 ml of water and 15 ml of ethanol. The pH is adjusted to 9.5 with 20% ammonium hydroxide and then 18 ml of 9% aqueous hydrogen peroxide solution are added. The mixture is left stirring at ambient temperature for 4 hours and then the precipitate formed is filtered off. 1.7 g of 3-amino-2-chloro-6-methyl-4-[(4-pyrrolidin-1-ylphenyl)imino]cyclohexa-2,5-dien-1-one (1m) are thus obtained.

Fuente