Reacción #74648

Ecuación de reacción

HCl

2-iodo-4-(trifluoromethoxy)phenol

potassium carbonate

3-cyano-4-fluoro-N-[1,2,4]thiadiazol-5-yl-benzenesulfonamide

→

title compound

3-cyano-N-(1,2,4-thiadiazol-5-yl)-4-[2-iodo-4-(trifluoromethoxy)phenoxy]benzenesulfonamide

Disolventes

ethyl acetate

Dimethylsulfoxide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe organic layer was collected
2. 2
   Lavadowashed with brine (20 mL)
3. 3
   Secadodried over sodium sulphate
4. 4
   Concentraciónconcentrated in vacuo
5. 5
   OtroThe residue was triturated in dichloromethane
6. 6
   Filtraciónfiltered

Procedimiento

To a suspension of 2-iodo-4-(trifluoromethoxy)phenol (Preparation 226, 600 mg, 1.97 mmol) and potassium carbonate (1125 mg, 8.14 mmol) in Dimethylsulfoxide (10 mL) was added 3-cyano-4-fluoro-N-[1,2,4]thiadiazol-5-yl-benzenesulfonamide (Preparation 65). The reaction was heated to 80° C. under N2 for 7 hours before the addition of ethyl acetate (20 mL) and 3M aqueous HCl solution (30 mL). The organic layer was collected, washed with brine (20 mL), dried over sodium sulphate and concentrated in vacuo. The residue was triturated in dichloromethane and filtered to afford 965 mg of the title compound.

Fuente