Reacción #745262

Ecuación de reacción

sodium hydroxide

Cyclohexanecarboxaldehyde

diethylamine hydrochloride

acetic acid

→

cyclohexylmethyl-ethyl-amine

Rendimiento 83.8%

Disolventes

methylene chloride

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe mixture is separated
2. 2
   Lavadothe organic layer is washed with a saturated brine
3. 3
   Secadodried over magnesium sulfate
4. 4
   Concentraciónthe mixture is concentrated under reduced pressure

Procedimiento

Cyclohexanecarboxaldehyde (38 g), diethylamine hydrochloride (55 g) and acetic acid (29 ml) are dissolved in methylene chloride (500 ml) and thereto is added triacetoxy sodium borohydride (71.8 g) at room temperature and the mixture is stirred at room temperature overnight. To the reaction solution are added a 2N-aqueous sodium hydroxide solution and methylene chloride, and the mixture is separated, and the organic layer is washed with a saturated brine, dried over magnesium sulfate, and the mixture is concentrated under reduced pressure to give cyclohexylmethyl-ethyl-amine (40.1 g) as a crude product. MS (m/z): 142 [M+H]+

Fuente