Reacción #74507

Ecuación de reacción

5-bromo-2-chloro-4-methoxybenzonitrile

NaOH

EtOH

→

title compound

5-Bromo-2-chloro-4-methoxybenzoic acid

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed overnight
2. 2
   OtroEtOH was removed under reduced pressure
3. 3
   workup.ADDITIONThe mixture was diluted with water and neutralized with hydrochloric acid (3.0 N)
4. 4
   FiltraciónThe resulting solid was filtered
5. 5
   Otrodried in vacuo

Procedimiento

A mixture of 5-bromo-2-chloro-4-methoxybenzonitrile (30.7 g, 124 mmol) and NaOH (127 g, 3.11 mol) in EtOH (500 mL) and water (250 mL) was refluxed overnight. After cooling to room temperature, EtOH was removed under reduced pressure. The mixture was diluted with water and neutralized with hydrochloric acid (3.0 N). The resulting solid was filtered and dried in vacuo to give title compound (32.9 g, quantitative) as a white solid.

Fuente