Reacción #74503

Ecuación de reacción

water

2,4-dichlorobenzoic acid

compound 80

2,4-dichlorobenzoic acid

bromine

→

title compound

Rendimiento 187.5%

5-Bromo-2,4-dichlorobenzoic acid

Rendimiento 187.5%

Disolventes

chlorosulfonic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled to ambient temperature
2. 2
   OtroThe resulting solid was isolated by filtration
3. 3
   Otrodried in vacuo

Procedimiento

To a solution of 2,4-dichlorobenzoic acid (compound 80, 25.0 g, 131 mmol) in chlorosulfonic acid (100 mL) was added bromine (3.4 mL, 65 mmol) and sulfur (0.20 g, 6.6 mmol). The reaction mixture was stirred at 70° C. overnight and then cooled to ambient temperature. The reaction mixture was poured into iced water. The resulting solid was isolated by filtration and dried in vacuo to yield title compound (32.9 g, 93%) as pale brown solid.

Fuente