Reacción #74427

Ecuación de reacción

2-((1S,2S)-2-(benzyloxy)cyclohexylamino)-5-isopropyl-5-methylthiazol-4(5H)-one

iodotrimethylsilane

→

2-((1S,2S)-2-hydroxycyclohexylamino)-5-isopropyl-5-methylthiazol-4(5H)-one

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe vial was sealed
2. 2
   ConcentraciónThe reaction was concentrated
3. 3
   Otropurified by column chromatography (2% to 7% MeOH/DCM)

Procedimiento

A 5 mL vial was charged with 2-((1S,2S)-2-(benzyloxy)cyclohexylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (0.100 g, 0.28 mmol) and 1 mL of DCM. To this was added iodotrimethylsilane (0.22 g, 1.1 mmol). The vial was sealed and heated at 65° C. for 36 h. The reaction was concentrated and purified by column chromatography (2% to 7% MeOH/DCM) to give 2-((1S,2S)-2-hydroxycyclohexylamino)-5-isopropyl-5-methylthiazol-4(5H)-one as a yellow solid

Fuente