Reacción #742274

Ecuación de reacción

cefaclor

cefaclor

ammonia

→

cefaclor monohydrate

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otro30 min
2. 2
   Otroat 30° C.
3. 3
   Otro30 min
4. 4
   Otroat 25° C.
5. 5
   Otro60 min
6. 6
   Otroat 20° C
7. 7
   FiltraciónThe suspension was filtered through a glass
8. 8
   Filtraciónfilter
9. 9
   Lavadothe wet cake was washed with one volume of water and two volumes of acetone
10. 10
    OtroAfter drying

Procedimiento

A crystallisation reactor was filled with 34 g water and 1.0 g cefaclor as seed. The above-mentioned acidic cefaclor solution was dosed into the crystallisation reactor in 60 minutes at 35° C. The pH was kept at 5.0 with ammonia. Subsequently, the temperature was lowered in steps: 30 min at 30° C., 30 min at 25° C., and 60 min at 20° C. The suspension was filtered through a glass filter and the wet cake was washed with one volume of water and two volumes of acetone. After drying, 15.7 g cefaclor monohydrate was obtained (purity 99.4%).

Fuente