Reacción #742252

Ecuación de reacción

3-(2-hydroxy-phenyl)-acrylic acid ethyl ester

dec-9-en-1-ol

→

colourless crystals

Rendimiento 21.5%

(E)-3-(2-Hydroxy-phenyl)-acrylic acid dec-9-enyl ester

Rendimiento 21.5%

Disolventes

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroremoving the ethanol
2. 2
   Otroformed
3. 3
   Temperaturathe reaction mixture was cooled
4. 4
   Lavadowashed with brine
5. 5
   OtroThe organic phase was dried
6. 6
   Otroevaporated to dryness
7. 7
   workup.DISTILLATIONThe resulting oil was Kugelrohr-distilled
8. 8
   Otrocrystallized
9. 9
   Otrorecrystallized

Procedimiento

A mixture of 5.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester, 6.1 g dec-9-en-1-ol and 1.0 g tetraisopropyl-ortho-titanate was heated to 150° C. removing the ethanol formed. After stirring for 2.5 hours at this temperature, the reaction mixture was cooled, diluted with ether and washed with brine. The organic phase was dried and evaporated to dryness. The resulting oil was Kugelrohr-distilled, crystallized and recrystallized to yield 1.69 g of colourless crystals.

Fuente