Reacción #742249

Ecuación de reacción

ethoxycarbonylmethylenetriphenylphosphorane

toluene

1-(4-diethylamino-2-hydroxy-phenyl)ethanone

→

3(4-Diethylamino-2-hydroxy-phenyl)-but-2-enoic acid ethyl ester

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThen the reaction mixture was heated to reflux
2. 2
   TemperaturaAfter refluxing for 31 hours the mixture
3. 3
   Temperaturawas cooled down
4. 4
   Otroevaporated to dryness
5. 5
   OtroThe resulting dark oil was purified by chromatography
6. 6
   Otroto yield a colourless oil

Procedimiento

To a suspension of 5.27 g ethoxycarbonylmethylenetriphenylphosphorane in 10 ml of toluene, a solution of 2.02 g 1-(4-diethylamino-2-hydroxy-phenyl)ethanone (DE 28 44 606) was dropped in at room temperature. Then the reaction mixture was heated to reflux. After refluxing for 31 hours the mixture was cooled down and evaporated to dryness. The resulting dark oil was purified by chromatography to yield a colourless oil.

Fuente