Reacción #74050

Ecuación de reacción

sodium carbonate

4-cyanophenylboronic acid

ethyl 2-(3-bromopyridin-4-ylthio)-2-methylpropanoate

acetonitrile

→

ethyl 2-(3-(4-cyanophenyl)pyridin-4-ylthio)-2-methylpropanoate

Rendimiento 70.0%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe resulting mixture was degassed by nitrogen bubbling for 1 minute

Procedimiento

To a mixture of 4-cyanophenylboronic acid (49 mg, 0.33 mmol) and Pd(dppf)Cl2 (9 mg, 5% mole) were added a solution of freshly purified ethyl 2-(3-bromopyridin-4-ylthio)-2-methylpropanoate from (step B, 67 mg, 0.22 mmol) in THF (1 mL), acetonitrile (0.5 mL), and sodium carbonate (1M aqueous, 0.5 mL). The resulting mixture was degassed by nitrogen bubbling for 1 minute, and then heated to 150° C. for 30 minutes under microwave irradiation. The mixture was loaded on to a 5 g ISCO loading cartridge and eluded with a gradient of 0-100% ethyl acetate in hexane on a 12 g ISCO column to yield ethyl 2-(3-(4-cyanophenyl)pyridin-4-ylthio)-2-methylpropanoate (0.049 g, 70%).

Fuente