Reacción #73984

Ecuación de reacción

methacryloyl chloride

trimethylsilyl propyn-1-ol

Et3N

→

2-Methyl-acrylic acid 3-trimethylsilanyl-prop-2-ynyl ester

Disolventes

Et2O

Et2O

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAny precipitated ammonium salts can be removed by filtration, and volatile components
2. 2
   Otrocan be removed under reduced pressure
3. 3
   OtroThe crude product is then purified by flash chromatography

Procedimiento

A solution of trimethylsilyl propyn-1-ol (1 g, 7.8 mmol) and Et3N (1.4 mL, 10 mmol) in Et2O (10 mL) is cooled to −20° C. and a solution of methacryloyl chloride (0.9 mL, 9.3 mmol) in Et2O (5 mL) is added dropwise over 1 h. The mixture is stirred at this temperature for 30 min, and then allowed to warm to ambient temperature overnight. Any precipitated ammonium salts can be removed by filtration, and volatile components can be removed under reduced pressure. The crude product is then purified by flash chromatography.

Fuente