Reacción #73902

Ecuación de reacción

methyl N-[1-(benzofuran-5-yl)-2-(dimethylamino)-2-oxoethyl]-L-leucinate

lithium hydroxide

→

N-[1-(benzofuran-5-yl)-2-(dimethylamino)-2-oxoethyl]-L-leucine

Rendimiento 95.8%

Disolventes

methanol

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas removed in vacuo
2. 2
   workup.ADDITIONThe residue was diluted with water (10 ml)
3. 3
   Lavadoeluted with water (×2) and methanol (×2)
4. 4
   Otroevaporated

Procedimiento

To a solution of methyl N-[1-(benzofuran-5-yl)-2-(dimethylamino)-2-oxoethyl]-L-leucinate (520 mg) in methanol (5 ml) was added a solution of lithium hydroxide (91 mg) in water (3 ml). After stirring vigorously for 24 hours the solvent was removed in vacuo. The residue was diluted with water (10 ml) then neutralised with 2N hydrochloric acid. This solution was applied to an Oasis™ cartridge (2×6 g) and eluted with water (×2) and methanol (×2). The required fractions were combined and evaporated to afford N-[1-(benzofuran-5-yl)-2-(dimethylamino)-2-oxoethyl]-L-leucine (478 mg).

Fuente