Reacción #737100

ord-512ac53ee0cd425d92c08f04d06dc8a0

Ecuación de reacción

CCOC(=O)c1c(Nc2ccccc2[N+](=O)[O-])sc2cc(OC)ccc12
ethyl 6-methoxy-2-(2-nitroanilino)benzo[b]thiophene-3-carboxylate
[H][H]
hydrogen
→
CCOC(=O)c1c(Nc2ccccc2N)sc2cc(OC)ccc12
ethyl 2-(2-aminoanilino)-6-methoxybenzo[b]thiophene-3-carboxylate

Reactantes

CCOC(=O)c1c(Nc2ccccc2[N+](=O)[O-])sc2cc(OC)ccc12
ethyl 6-methoxy-2-(2-nitroanilino)benzo[b]thiophene-3-carboxylate
[H][H]
hydrogen

Reactivos

[C].[Pd]
palladium-carbon

Disolventes

CCOC(C)=O
ethyl acetate

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroMaterial Synthesis Example 19

Procedimiento

In the same manner as in Starting Material Synthesis Example 19 and using ethyl 6-methoxy-2-(2-nitroanilino)benzo[b]thiophene-3-carboxylate, ethyl acetate, 10% palladium-carbon and hydrogen (60 atm kg/cm2), ethyl 2-(2-aminoanilino)-6-methoxybenzo[b]thiophene-3-carboxylate is obtained.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06271225B1uspto-grants-2001_08