Reacción #736396

Ecuación de reacción

4-chloro-3-methoxy-2-methyl-pyridine

2,2,3,3,3-pentafluoropropanol

potassium tert-butoxide

→

3-methoxy-2-methyl-4-(2,2,3,3,3-pentafluoropropoxy)pyridine

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter being refluxed for 40 hours
2. 2
   workup.ADDITIONwas added
3. 3
   Filtraciónthe insoluble substance was filtered off
4. 4
   ConcentraciónThe filtrate was concentrated
5. 5
   Otropurified by column chromatography

Procedimiento

To 2,2,3,3,3-pentafluoropropanol (21 ml) were added in small portions, potassium tert-butoxide (23.6 g) and then 4-chloro-3-methoxy-2-methyl-pyridine (7.5 g). After being refluxed for 40 hours, the reaction mixture was cooled, to which ethyl acetate was added and the insoluble substance was filtered off. The filtrate was concentrated and purified by column chromatography, to give 3-methoxy-2-methyl-4-(2,2,3,3,3-pentafluoropropoxy)pyridine (1.7 g) as a light yellow oil while 4.1 g of the starting material was recovered at the same time.

Fuente