Reacción #736395

Ecuación de reacción

4-chloro-3-methoxy-2-methylpyridine

2,2,2-trifluoroethanol

potassium t-butoxide

→

3-methoxy-2-methyl-4-(2,2,2-trifluoroethoxy)pyridine

Rendimiento 46.8%

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated
2. 2
   workup.ADDITIONdiluted with water
3. 3
   Extracciónextracted twice with chloroform
4. 4
   SecadoThe extract was dried, from which chloroform
5. 5
   Otrowas evaporated
6. 6
   Otrothe residue was purified by column chromatography on silica gel (chloroform-methanol (400:9))

Procedimiento

A mixture of 4-chloro-3-methoxy-2-methylpyridine (7.8 g), 2,2,2-trifluoroethanol (24.7 g) and potassium t-butoxide (27.76 g) was heated at 110° C. for 18 hours, then concentrated, diluted with water, and extracted twice with chloroform. The extract was dried, from which chloroform was evaporated, and the residue was purified by column chromatography on silica gel (chloroform-methanol (400:9)), to give 3-methoxy-2-methyl-4-(2,2,2-trifluoroethoxy)pyridine (5.12 g) as a white or pale yellow solid.

Fuente