Reacción #736393

Ecuación de reacción

4-Chloro-3-methoxy-2-methylpyridine

sodium

ethanol

→

4-ethoxy-3-methoxy-2-methyl-pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe solution was refluxed
2. 2
   Temperaturaby heating for 10 hours
3. 3
   OtroThe solvent was evaporated
4. 4
   workup.ADDITIONthe residue was added to ice water, which
5. 5
   Extracciónwas extracted with chloroform
6. 6
   Lavadowashed with water
7. 7
   Otrodried
8. 8
   Otroevaporated
9. 9
   OtroThe residue was purified by column chromatography on silica gel

Procedimiento

4-Chloro-3-methoxy-2-methylpyridine (3.14 g) was added to a solution of sodium (2.0 g) in ethanol (30 ml), and the solution was refluxed by heating for 10 hours. The solvent was evaporated and the residue was added to ice water, which was extracted with chloroform, washed with water, dried and evaporated. The residue was purified by column chromatography on silica gel, to give 4-ethoxy-3-methoxy-2-methyl-pyridine (2.6 g) as a light brown oil.

Fuente