Reacción #73427

Ecuación de reacción

1-methyl-1H-pyrazol-3-amine

acetonylacetone

water

water

→

3-(2,5-Dimethyl-pyrrol-1-yl)-1-methyl-1H-pyrazole

Disolventes

toluene

AcOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   ConcentraciónConcentrated
3. 3
   Otroto dry
4. 4
   OtroThe residue is purified by flash column
5. 5
   Otroto give product

Procedimiento

To a solution of 1-methyl-1H-pyrazol-3-amine (9.5 g, 98 mmol) and acetonylacetone (11.2 g, 98 mmol) in toluene (150 mL), AcOH (1.5 mL) is added, heated to reflux with a water separator until the formation of water ceased. Concentrated to dry. The residue is purified by flash column to give product.

Fuente