Reacción #73358

Ecuación de reacción

4-[benzyl-(1-ethoxycarbonyl-ethyl)-amino]-butyric acid methyl ester

potassium tert-butoxide

→

(±)-1-Benzyl-2-methyl-3-oxo-piperidine-4-carboxylic acid methyl ester

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture is then partitioned between DCM and saturated aqueous NH4Cl
2. 2
   OtroThe organic layer is removed
3. 3
   Secadodried over anhydrous Na2SO4
4. 4
   Concentraciónconcentrated
5. 5
   OtroThe crude residue is used without further purification

Procedimiento

A mixture of 4-[benzyl-(1-ethoxycarbonyl-ethyl)-amino]-butyric acid methyl ester (1.5 g, 4.9 mmol), potassium tert-butoxide (906 mg, 8.9 mmol) and toluene (100 mL) is stirred at rt for 3 h. The mixture is then partitioned between DCM and saturated aqueous NH4Cl. The organic layer is removed, dried over anhydrous Na2SO4, and concentrated. The crude residue is used without further purification.

Fuente