Reacción #7313

Ecuación de reacción

1-(5-chlorobenzotriazol-1-yl)-propan-2-one

ethanol

sodium cyanide

ammonium chloride

→

2-amino-3-(5-chlorobenzotriazol-1-yl)-2-methylpropionitrile

Disolventes

—

solution

ammonia

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture is subsequently concentrated by evaporation in a vacuum
2. 2
   workup.DISSOLUTIONdissolved again in ethyl acetate
3. 3
   Lavadowashed with water and saturated sodium chloride solution
4. 4
   OtroThe organic phase is separated
5. 5
   Secadodried with magnesium sulphate
6. 6
   Concentraciónconcentrated by evaporation

Procedimiento

240 mg of 1-(5-chlorobenzotriazol-1-yl)-propan-2-one are dissolved in 4 ml of a 2-molar solution of ammonia in ethanol, then 64 mg of sodium cyanide and 91 mg of ammonium chloride are added and the mixture is stirred over night at room temperature. The reaction mixture is subsequently concentrated by evaporation in a vacuum, dissolved again in ethyl acetate, and washed with water and saturated sodium chloride solution. The organic phase is separated, dried with magnesium sulphate and concentrated by evaporation. 2-amino-3-(5-chlorobenzotriazol-1-yl)-2-methylpropionitrile is thus obtained.

Fuente