Reacción #73066

Ecuación de reacción

Nitromethane

1-methyl-4-piperidone

→

1-methyl-4-nitromethylpiperidin-4-ol

Rendimiento 73.4%

Disolventes

ethanol

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGThe reaction mixture was stirred at ambient temperature for 2 days
2. 2
   Filtraciónfiltered
3. 3
   LavadoThe isolated solid was rinsed with ether

Procedimiento

Nitromethane (6.6 mL, 122.0 mmol) and sodium methoxide (0.94 mL of 25 wt % in methanol, 4.1 mmol) were added to a solution of 1-methyl-4-piperidone (10 mL, 81.3 mmol) in ethanol (10 mL). After 30 minutes more ethanol (15 mL) was added to facilitate stirring. The reaction mixture was stirred at ambient temperature for 2 days and then filtered. The isolated solid was rinsed with ether to provide 10.39 g of 1-methyl-4-nitromethylpiperidin-4-ol as a white powder. An additional 1.18 g was isolated from the filtrate.

Fuente